The Role of the IL23/IL17 Axis in Bronchiolitis Obliterans Syndrome After Lung Transplantation
نویسندگان
چکیده
منابع مشابه
Bronchiolitis Obliterans After Lung Transplantation
ing lung transplantation is 71%, and 46% of trans¬ plant recipients will survive at least 5 years.1 Al¬ though infections, medication-related adverse events, and malignancies remain important compli¬ cations, prolonged survival is limited predominantly by bronchiolitis obliterans (RO), a condition that was associated with transplantation more than a decade ago.25 Data suggest that at least 50% ...
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Bronchiolitis obliterans syndrome (BOS) is a severe complication after lung transplantation (LTX). In a retrospective cohort study 12 stable healthy recipients (non-BOS) and eight patients with BOS were enrolled after LTX and matrix metalloproteinases (MMP)-9, TIMP-1 and cell characteristics in bronchoalveolar lavage (BAL) samples (n = 145) were analysed. BALs from patients with BOS were furthe...
متن کاملBronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation.
Lung transplantation is a therapeutic option for patients with end-stage pulmonary disorders. Unfortunately, chronic lung allograft dysfunction (CLAD), most commonly manifest as bronchiolitis obliterans syndrome (BOS), continues to be highly prevalent and is the major limitation to long-term survival. The pathogenesis of BOS is complex and involves alloimmune and nonalloimmune pathways. Clinica...
متن کاملCytolytic therapy for the bronchiolitis obliterans syndrome complicating lung transplantation.
UNLABELLED The bronchiolitis obliterans syndrome (BOS) is the major cause of late morbidity and mortality after lung transplant (LTx). Previous studies suggest cytolytic therapy may be effective for the BOS but this therapy has not been proved effective or safe. METHOD A retrospective study of a predetermined treatment regimen to determine if the rate of fall in FEV1 can be reduced by cortico...
متن کاملBronchiolitis obliterans following lung transplantation.
Bronchiolitis obliterans syndrome (BOS) is the main and late chronic complication after lung transplantation. It remains a major impediment to long-term outcome. Unfortunately, the survival rate of lung transplant recipients lags behind that of other organ transplant recipients, and BOS accounts for more than 30% of all mortality after the third year following lung transplantation. Most recent ...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2008
ISSN: 1600-6135,1600-6143
DOI: 10.1111/j.1600-6143.2008.02321.x